Evaluation of Aqueous Leaf Extract +of Phyllantus Niruri in Vitro

The toxicity effect of Chanca piedra (Phyllanthus niruri)leaves extract was studied on albino rats. Rats were divided into four groups, per group. Group 1 received water and feeds only, whileonly. Groups 2, 3, 4 administered doses the 200 mg/kg, 400 800 mg/kg body weight respectively. Parameters indices liver kidney function. Results showed that final weight, serum, AST, ALP, urea, Creatinine, some electrolytes not affected by administration different extract. ALT significantly increased when compared with control. Besides, there asignificant increase in level K+ (P>0.05) at dose 200mg/kg Similarly, Na+ also (400 mg/kg). These increases observed may be due to certain phytochemicals present longer could likely safe.